It's a virus problem!
Imagine 3 people A, B, and C. A knows B, and B knows C, but A and C do not know each other. In this scenario, B has both A's and C's email addresses stored on his computer.
Now person B gets a virus on his computer, and the virus creates an email message, randomly grabs two email addresses, puts one of them (A) into the "from" line, and the other (C) in the "to" line, and sends the email off. Now person C gets an email from A, a person he doesn't know, and assumes A is a spammer. He sends a nasty email to A saying "are you a spammer?"
That answers the second part of your question. To answer the first part, imagine that person C has changed his email address, so the email address the virus sends to is invalid. So what happens? Since the virus has forged A into the "From" line, it is A who gets the "delivery failure" notifications, even though he never sent out an email.
Is there anything you can do about it? Not a thing. Sorry.
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